Sex and Lyme Disease

By Robert C Bransfield, M.D.


How does chronic Lyme disease affect sexual functioning, and how can it be treated? Lyme can affect sexual functioning by its effect upon the cen­tral nervous system, the endocrine system, the auto­nomic nervous system, the peripheral nervous system, and/or the body.

It is well recognized that Borrelia burgdorferi (Bb) causes depression, obsessiveness, panic disor­der, and phobias that are functions of the emotional aversive pathways of the brain. However, we can also see dysfunction of the reward pathways as well, which affect capacity for pleasure, feeding, bonding and sex. Since Lyme disease alters the aversive pathways which affect what and who we are repelled from, it is understandable that Lyme can also alter sexual at­traction and behavioral patterns as well. With this in mind, I shall begin with some patient accounts and observations.


Sexual arousal:

            Most patients report a decline in both libido and overall sexual functioning. Some state that their interest in sex and sexual functioning remain normal while a few report increased libido. One such patient described a greatly increased libido, but was frustrated because the multitudes of chronic Lyme disease symptom made it painful to be touched and/or hugged. Others describe increased libido associ­ated with hypnagogic hallucinations. A patient with this symptom was described in the medical literature two years ago. She displayed sexual obsessions, sexual hallucinations, and a tendency to compulsively masturbate in a dream-like state eighteen hours per day if left undisturbed.*

Some patients develop an obsessive compul­sive disorder with sexual obsessions, compulsions, intrusive images, and vivid dreams following the on­set of chronic Lyme disease. Of particular interest, a few patients report a change in the content of sexual imagery. A change to more violent sexual themes is sometimes noted. This, in turn, sometimes altars sexual behavior.

Could Borrelia burgdorferi or other infectious diseases sometimes alter sexual orientation or contribute gen­der dysphoria, or altered patterns of sexual arousal? There is evidence that sexual functioning is altered by a number of other parasites, including Wolbachia, Spiroplasma, Rickettsia and Microsporidia. When Bb infections begin in childhood, are there some cases where it may have an effect upon sexual development? Is infectious disease one of the many factors that may affect sexual development? When changes in sexual imagery occur in adults, most are upset by the changes, which result in a decline of sexual interest. However, there are times when some individuals act out these fantasies.

*Stein Sara L., MD. Et al, American Journal of Psychiatry 153:4, April 1996, Clinical Case Conference “A 25- Year-Old Woman With Hallucinations, Hyper sexuality, Nightmares, and a Rash.”



         Patients complain of infertility with surprising fre­quency. Is infertility more common in chronic Lyme disease patients?


Atrophy of genitalia:

         A few patients who have been infected for over ten years report atrophy of the genitalia. Males have reported atrophy of

the penis and testicles, a change that is reversed by IV antibiotics. Females report lack of vaginal lubrication, painful intercourse, and anorgasmia. One female patient reported atrophy of one breast.


Anesthesia of genitalia:

On occasion, some patients complain of a loss or sensation of the genitalia. I have also seen this symptom in a few chronic fatigue patients.


Orgasm induced migraine headaches:

Although uncommon, this is seen in chronic Lyme disease patients.


Lymphocytoma of the nipple:

This has been reported In Europe, but I have never seen such a case in my practice.


Menstrual irregularity:

A common symptom in about 50% of men­struating patients.


Breast swelling, tenderness, and lactation:

Some patients complain of this symptom.


Premenstrual Syndrome:

There is a significant tendency towards wors­ening of the chronic Lyme disease symptoms in the premenstrual period.


Besides these symptoms associated with Lyme disease, there are many other symptoms which indirectly affect sexual functioning, i.e. - fatigue, chronic pain, depression, paranoid, hyper vigilance, mood swings, low frustration tolerance, temper outbursts, apathy, etc. These mood symptoms often alienate their partners. It is no surprise that many chronic Lyme dis­ease patients report marital discord.



A well-planned treatment approach for chronic Lyme disease can help the overall prognosis, thereby possibly helping any of these symptoms. The treat­ment of sexual dysfunction is one of the last frontiers in medicine. Three new drugs for male erectile dys­function are approaching approval for marketing. The first will be Viagra, developed by Pfizer. Loss of li­bido and a loss of sexual functioning are treated by a number of methods Testosterone treatments are sometimes effective for loss of libido in both men and women. Dopamine agonists such as Wellbutrin and Parlodel are also used as treatment modalities.

More interesting than the treatment of sexual dysfunction is the question - can some individuals with abnormal patterns of sexual arousal be treated with antibiotics?